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In the SURMOUNT-1 body-composition substudy, about 74% of the total weight lost on tirzepatide came from fat mass rather than lean mass, and MRI showed visceral (intra-abdominal) fat fell by roughly a third, substantially more than placebo

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We estimated NADP + and NADPH levels in fresh blood based on concentrations measured in frozen samples

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Oxidative stress within the tumor microenvironment can suppress the anti-tumor immune response by inducing the apoptosis of cytotoxic T cells and natural killer (NK) cells, which are crucial for targeting and eliminating cancer cells [122]

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