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Tirzepatide (Mounjaro/Zepbound) Timeline Phase 3 trials began: 2019 (SURPASS program for diabetes) FDA approval (Mounjaro for diabetes): May 2022 Commercial availability: June 2022, initial supply constraints Zepbound (obesity indication) Phase 3: 2020-2022 (SURMOUNT program) Zepbound FDA approval: November 2023 Zepbound commercial launch: December 2023, immediate shortages Stable widespread availability: Still not fully stable as of early 2026

TL;DR Ozempic delivers superior results for weight loss (up to 15% body weight reduction vs Januvias 2-4 lbs) and HbA1c reduction (1.5-1.8% vs 0.6-0.8%)

The company claimed it contained the same active ingredient (semaglutide) found in Wegovy and Ozempic

The data Lilly presented was apparently compelling enough to warrant that level of response