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Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ

The receptor is now recognized as a promising target for modulating neuroinflammation and microglia-mediated neuronal survival, particularly following the discovery of A 2A receptor upregulation in microglia from the prefrontal cortex of AD patients [483]

Compared with other forms of cell death such as apoptosis, necrosis, and autophagy, ferroptosis exhibits distinct molecular mechanisms and biological features ( Table 1 ): (1) Iron Dependence: Ferroptosis is uniquely triggered by elevated intracellular iron levels, differentiating it from other cell death modes

Its stability characteristics allow for extended observation periods, making it suitable for longitudinal assay designs and comparative analysis studies