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implications for threshold and meaningful change estimation Helen Doll 1 , Michael DeRosa 2 , Shruti Dave 2 , Alyssa Bamer 3 1 Clinical Outcomes Solutions, Folkestone, UK, 2 Clinical Outcomes Solutions, Chicago, Illinois, USA, 3 Clinical Outcomes Solutions, Tucson, Arizona, USA Journal of Patient-Reported Outcomes 2026 , 10(Suppl 1) :301.5 Aims Receiver operating characteristic (ROC) curve analysis is often used to estimate thresholds related to meaningful change or condition severity

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However, compounded medications are not FDA-approved finished products, and the FDA does not evaluate compounded formulations for safety, effectiveness, or quality in the same manner as FDA-approved brand-name drugs