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The most common side effects include: peripheral edema (15%), nausea (14.3%), dizziness (12.9%), fatigue (12.1%), ascites (11.4%), diarrhea (10.7%), headache (10%), muscle spasms (9.3%), itchiness (9.3%), and abdominal pain (8.6%)

For some, the only option has been to resort to compounded drugs for which the Food and Drug Administration has not assured the safety, and for which the main pharmaceutical ingredient is made in Chinese chemical factories without the quality standards of FDA-approved branded drugs

These structural differences between semaglutide and tirzepatide obviously have consequences for their biological actions