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By delivering glutathione past the digestive tract, injections sidestep the poor absorption that limits capsules, which is the core reason injection therapy reaches meaningful levels when oral dosing often cannot

This assessment is even more relevant if it is considered that the oxidized state would lead to an intramolecular disulfide bond, which usually could not lead to a single reduced Cys residue under reducing conditions, but must allow two bonds with mPEG-MAL, unless the second Cys residue is structurally or spatially hidden

E., Shataeva, L

Scanning the indexed literature, the human clinical work is essentially confined to that window