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Another study also carried out in HEK-293 cells showed that incretin heterodimers can form constitutively and that stimulation of GLP-1R with GLP-1 promotes incretin heterodimerisation whereas GIP stimulation reduces it ( q and -arrestin recruitment to the GLP-1R whereas GLP-1 stimulation enhances recruitment of G s to the GIPR

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Protein-precursors Among those eager to try out genetic engineering techniques was Joel Habener (figure 21), a medical graduate from the University of California Los Angeles, who joined Massachusetts General Hospital (MGH) in 1969 where he completed his clinical training in internal medicine

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