Summary of phase 2 clinical trials of GLP1R agonists for PD Ex-4: exenatide-4, mTOR: mechanistic target of rapamycin, IRS1: insulin receptor substrate 1, MDS-UPDRS: Movement Disorder Society-Sponsored Revision of the Unified Parkinsons Disease Rating Scale, PD: Parkinsons disease, PKB: protein kinase B, DAergic: dopaminergic, GLP1R: glucagon-like peptide-1 receptor.
doi: 10.1016/j.hbpd.2021.04.007 165 ZhangNYaoHZhangZLiZChenXZhaoYet al
GLP-1 is a hormone naturally released by the gut after meals, Anekwe told Healthcare Brew
For example: At 0.25 mg semaglutide from a 5 mg/mL vial, you only draw 0.05 mL, delivering just 0.025 mg (25 mcg) of B12 At 2.4 mg from the same vial, you draw 0.48 mL, delivering 0.24 mg (240 mcg) of B12 The recommended daily intake of B12 for adults is 2.4 mcg