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secondary outcomes include the incidence of treatment with anti-VEGF injections, laser photocoagulation, or vitrectomy

[2] The second part of the ESSENCE trial will extend to 240 weeks, focusing on whether semaglutide lowers the risk of liver-related clinical events compared with placebo.1 Findings are expected to read out in 2029

While cross-trial comparisons are limited by differences in patient populations and study duration, the head-to-head percentage is clear: Retatrutides triple-action mechanism has generated the highest average weight loss percentage reported to date for any single pharmacological agent

& Maiorino, M