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Triptans (serotonin 5-HT1B/1D receptor agonists) work by constricting cranial blood vessels and blocking pain signals in the brain, providing targeted relief from migraine attacks
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The non-enzymatic mitochondrial protein hyperacetylation induced by the increased availability of mitochondrial acetyl-CoA avoids the risk associated with mitochondria overfeeding, restraining the activity of the respiratory complex I and modulating CACT activity
However, that debate was extinguished in a landmark 2015 publication in the European Journal of Nutrition
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