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This long loop is disordered in the crystal structure of c-MET/InlB complex 24 , but displays well-defined density in our cryo-EM map of c-MET/HGF holo-complex, suggesting that HGF recognizes this loop in an induced-fit manner
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In other words, if your body doesn't have enough B12, your metabolism suffers and slows down, encouraging your body to accumulate extra fat
These peptides mimic the spatial conformation of the parent (native) molecules while exhibiting significantly enhanced resistance to enzymatic degradation, thereby enabling prolonged biological activity and reduced immunogenicity
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