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New Trends in the Field Triple-agonist therapies approaching weight loss levels previously seen only with bariatric surgery Oral formulations that eliminate the need for injections, improving access and patient preference Monthly or less frequent dosing options to improve adherence Enhanced understanding of how combining different hormonal pathways can optimize weight loss and metabolic health Weight Loss Medications in the Pipeline Researchers are evaluating several promising agents in late-stage clinical trials: Retatrutide : A triple GIP/GLP-1/glucagon receptor agonist that demonstrated weight loss of approximately 24% at 48 weeks on the 12 mg dose