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Semaglutide is a medication used for both the treatment of type 2 diabetes and for long-term weight management in adults with obesity
Through the p62Keap1NRF2 pathway, NRF2 upregulates the expression of genes involved in iron and ROS metabolism, such as NQO1 , HO1 , and FTH1 , thereby suppressing ferroptosis (99)
During acute ICH, GSH treatment enhances antioxidant capacity, reduces brain infarct size, improves neurological deficits, and lowers mortality in ICH mice (211)
We do have small early human data measuring semaglutide in breast milk
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