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Mechanistically, the antioxidant capacity of OSR is largely attributed to its ability to induce and stabilize GPX4, a seleniumdependent enzyme that neutralizes lipid peroxides and serves as a central safeguard against ferroptotic cell death 25,26 .Mechanistic analyses revealed that OSR promotes GPX4 expression at both the transcriptional and translational stages and engages in direct binding with GPX4, validated through computational docking and CETSA experiments

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Sido et al, 1998), the increase in -GCS in mucosa from TNBS-treated rats can be interpreted as an adaptive response to control the consequences of the stress induced by TNBS as -GCS-HS is known to be upregulated in response to divergent stressful conditions including oxidative stress or GSH depletion (Morales et al, 1997, 1998

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