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Zinc Deficiency: Regular use of glutathione can result in reduced zinc content in the body
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Significant caloric restriction and changes in body composition could potentially alter nutritional status, though evidence specifically linking GLP-1-associated weight loss to micronutrient deficiencies affecting muscle function is limited
This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured
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