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Additionally, histological assessment involved Tyrosine Hydroxylase (TH) staining in the substantia nigra to evaluate the integrity and potential restoration of dopaminergic neurons, with evaluations performed at 1 month and 3 months post-lesion

In human narcolepsy patients there is a significant reduction in the amount of detectable orexin A and orexin B as well as an 80%100% reduction in the number of neurons that contain detectable prepro-orexin mRNA

Because there is not enough high-quality human evidence to support routine clinical use and they are not currently approved for use in Humans by Health Canada or the FDA

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