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Anti-anxiety effects in rats at 0.5 g/kg (extremely low dose) produced effects within 12 minutes of intraperitoneal injection, including increased time exploring open/lighted maze areas, decreased immobile freeze reaction time, and increased exploration in open field tests

To maximize the benefits while minimizing potential irritation, its best to use copper peptides in the morning and tretinoin in the evening

and (c) the average axonal diameter