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CRD42022382594 Graphical Abstract Similar content being viewed by others Introduction Semaglutide, administered s.c., has shown superior efficacy compared with other glucose-lowering agents, including its oral formulation, in reducing HbA 1c and in facilitating weight loss in individuals with type 2 diabetes [1, 2]

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For female mice, three different doses were used from a titration experiment (Extended Data Fig