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employed a HFD-induced NAFLD mouse model with hepatocyte-specific ablation of the retinoic acid receptor-related orphan receptor (ROR) (ROR-LKO) to demonstrate that liraglutide alleviated hepatic steatosis via ROR-dependent autophagy activation, thus highlighting another mechanism of autophagy activation by GLP-1RAs [28]
Oral semaglutide (brand name Rybelsus ) is a GLP-1 receptor agonist approved for type 2 diabetes, but many clinicians and patients explore its potential for weight loss
It shows 30-50% decreases in new and recurrent CUD in patients with diabetes or obesity who were treated with semaglutide vs non-GLP-1 medications
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