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Along this line, a recent large case-control study from 2024 including 162,253 obese patients treated with GLP-1 RAs and a matched group of untreated patients found an association between GLP-1 RAs and increased risk of depression, anxiety and suicidal behavior [10]

If sleep disruption is a persistent issue, explore timing adjustments, evening eating habits, and sleep hygiene practices as primary interventions

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For instance, it is well known that these medicines, labelled as GLP-1 receptor agonists, can cause several gastrointestinal disturbances including bloating, nausea, and vomiting, all of which can make it harder for you to fall asleep and get about your day, which in turn contributes to fatigue