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Most headaches follow a predictable pattern: Peak during the first 2-4 weeks of treatment Often occur after dose increases Gradually improve with continued use Respond well to simple management strategies For the majority of patients who experience this side effect, headaches are transient and manageable, rather than a persistent problem

Multinucleated macrophages, another feature of aged ovaries, may serve as biomarkers of fibrotic progression 65

Patients should report new abdominal pain, persistent nausea, or changes in bowel habits promptly

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