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For researchers who are not seeing expected results, storage evaluation should be the first troubleshooting step, before considering dose changes, switching medications , or adding supplementary compounds like B12 formulations or niacinamide combinations

when GSH is taken orally, it has low bioavailability and is easily broken down by the stomach and is not effective

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Lipid AGEs are elevated in diabetic patients compared with healthy controls, and accumulation of lipid AGEs appears to contribute to vascular diseases related to diabetes (Fishman 2018)