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traditional therapies for type 2 diabetes: a simulation analysis

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6, Supplementary Figs S6 and S7, Table 3)

Although chronic intracerebroventricular infusion of native LEAP2 decreases body weight and ghrelin-induced weight gain [30, 90], these findings should primarily be considered proof-of-concept pharmacological effects, as the physiological relevance of endogenous central LEAP2 signalling remains uncertain

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