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Ernie Blevins, an endocrinologist at the University of Washington, and his colleagues co-administered oxytocin and a low dose of tirzepatide, a dual agonist mimicking the effects of both GLP-1 and glucose-dependent insulinotropic polypeptide, to obese rats and discovered that together, they produced more pronounced weight loss than either treatment alone

Among users who post about side effects, the most-discussed run nausea, fatigue, GI-other, anxiety, diarrhea, constipation, menstrual changes, and reflux/burps, in that order