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Nanomedicine platforms offer precise tools for macrophage modulation, enabling the targeted delivery of polarization-inducing agents directly to the TME while sparing peripheral tissues ( A multifunctional poly(amino acid) nanomedicine (PM-DPA/R848) has been developed that encapsulates the TLR7/8 agonist resiquimod (R848) within a nanocarrier composed of poly(L-methionine) and alendronate-functionalized DSPE-PEG ( Calcium carbonate (CaCO3)-based nanosystems have been engineered to simultaneously neutralize the acidic TME and reprogram TAM polarization

Rudnicka L, Kaczorowska A