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Serrano said that if symptoms went untreated, it could cause "irreversible damage" to the nervous system and lead to the inability to walk as normal, permanent muscle tightness, and loss of motor function in your legs
Indeed, the mechanisms involved in E2-mediated proliferation are associated with the inhibition of the tumor suppressor protein, p53, which, in turn, generates the downstream activation of cyclin-dependent kinases (CDKs) and, consequently, the release of the retinoblastoma protein (Rb) that promote the progression of the cell cycle by activating diverse transcription factors (Gompel et al., 2004)
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It also raises VEGF and FGF to help new blood vessels form, and lowers TGF-1 to reduce scarring giving a balanced repair response
