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It has recently been shown that a PEGylated GLP-1R/GcgR co-agonist could restore leptin sensitivity in DIO mice chronically maintained on a high-fat diet [73], and this may constitute one of the inherent weight-lowering actions of the co-agonist
10.1016/j.hgmx.2016.06.011 5 ChowanadisaiW.BauerlyK
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The recommended starting dose for type 2 diabetes is 2.5 mg once weekly, with gradual titration every four weeks based on glycemic response and tolerability, up to a maximum of 15 mg weekly
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