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placebo, when added to standard care, was evaluated in the SUSTAIN 6 trial for the formulation administered once-weekly subcutaneously and in PIONEER 6 for the new once-daily oral formulation
What This Study Teaches Us The review suggests cannabinoids, acting through CB1- and CB2-receptor-mediated pathways in the endocannabinoid system, may produce modest, patient-reported symptom benefits beyond pain, including reduced spasticity in multiple sclerosis, fewer seizures in treatment-resistant pediatric epileptic syndromes, antiemetic effects in refractory chemotherapy-induced nausea and vomiting, and appetite stimulation in cachectic states
Glutathione is a naturally occurring antioxidant that helps neutralise reactive oxygen species, supports cellular detoxification and protects tissues from oxidative damage
However, these tolerability issues ultimately impeded its regulatory and clinical progression
