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Mutagenesis 26, 147e152
Lean mass loss is clinically relevant because it reduces physical function and resting metabolic rate, potentially amplifying compensatory responses and increasing susceptibility to weight regain ( GLP-1RAs are not designed to exert anabolic effects on skeletal muscle
Acarbose blocks the intestinal enzyme alpha-glucosidase needed to digest complex carbohydrates (eg, starches) into simple sugars such as glucose that can be easily absorbed into the bloodstream
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