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This introduces variability in pharmacodynamics, as GLP-1RA penetration into specific brain regions may differ based on sex, compound properties, and age ( This raises important questions for ongoing trials such as EVOKE, which may uncover sex-specific differences and justify subsequent investigations of GLP-1 analogues in female populations
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33 Although decreases in gastric emptying via GLP-1RAs help prevent overnutrition by decreasing nutrient absorption, there is concern that patients could be at risk of nutrient deficiencies driven by malabsorption from delayed gastric emptying
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis
