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559 These predictions inform rational design of combination therapies that strategically exploit compensatory relationships rather than acting blindly upon isolated mechanisms

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Lincoff AM, Brown-Frandsen K, Colhoun HM, Deanfield J, Emerson SS, Esbjerg S, Hardt-Lindberg S, Hovingh GK, Kahn SE, Kushner RF, Lingvay I, Oral TK, Michelsen MM, Plutzky J, Torne CW, Ryan DH

This likely results from: Swelling within the carpal tunnel itself Proliferation of connective tissue surrounding the median nerve Increased fluid retention in the wrist region Individuals with pre-existing anatomical predisposition (narrow carpal tunnels, previous injury) are at higher risk