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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
Results: It typically takes a few weeks to see the full results of the treatment
(2008): Metabolic profiling of PPAR -/- mice reveals defects in carnitine and amino acid homeostasis that are partially reversed by oral carnitine supplementation
It also affects liver function, though primarily through indirect mechanisms involving insulin, glucagon, and neural pathways rather than direct hepatic action
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