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Abbasi BA, Iqbal J, Israr M, et al

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1 Introduction Mycophenolate mofetil (MMF), an ester prodrug of mycophenolic acid (MPA), is the predominant antimetabolite immunosuppressant that is used in combination with tacrolimus (TAC) or cyclosporine (CsA), with or without corticosteroids to prevent allograft rejection following solid organ transplantation ( When orally administered, MMF is absorbed and rapidly hydrolyzed by carboxylesterase into MPA, which is its active component