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We will also review the mechanism by which SNAC enhances absorption of oral semaglutide and highlight the key preclinical and clinical data that led to approval of the first orally administered GLP-1RA for T2D

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Studies have reported OCTN2 expression in respiratory epithelial cells and alveolar macrophages, which is especially high in the upper lung region [301], and OCTN2-mediated carnitine uptake plays an important role in maintaining respiratory cilia beating and airway mucociliary clearance function, helping to remove excess mucus and potentially harmful substances from the airway [302]