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Another available option is semaglutide, which shares similarities with tirzepatide in its dual ability to help manage blood sugar and help with weight loss

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It can treat obesity and type 2 diabetes, which are linked to fertility problems

The analysis further noted that the safety advantage of the combination of GLP-1 RA & Metformin is mechanistically rooted in complementary pathways where metformin's AMPK-mediated suppression of hepatic gluconeogenesis and enhancement of peripheral glucose uptake, alongside GLP-1 RA's glucose-dependent insulin secretion and modulation of gastric motility, together prevent excessive gastric emptying delay that drives GI intolerance