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Harati, R., Villgier, A.-S., Banks, W
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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation
Yes, taking both is generally safe as B vitamins are water-soluble, but you may receive excessive amounts of certain vitamins, particularly B6 and niacin
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