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B12 deficiency is most common in individuals with conditions like pernicious anemia, certain gastrointestinal disorders (such as Crohns disease or celiac disease), or those who have had gastric surgery

Heres how specific conditions can impact the use of B12 shots: Heart Disease: While B12 is essential for overall health, excessive amounts of vitamin B12 in the body may sometimes cause an increase in certain heart disease risk markers, particularly for individuals with pre-existing cardiovascular conditions

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Once-weekly dosing: Tirzepatide is administered once a week by subcutaneous injection, which offers convenience and may improve treatment adherence