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Patients in the initial titration period (particularly at 0.25 mg or 0.5 mg weekly) may not yet experience the full appetite-suppressing effects

SGLT2 inhibitors (medicines ending in '-flozin') are typically stopped 3 days before surgery (4 days for ertugliflozin) due to the risk of diabetic ketoacidosis

Cell culture and bioluminescence analysis T cells, isolated from mice, were activated by CD3/CD28 Streptamer kit (#6-8920, iba, Goettingen, Germany) for 30 min and cultured in RPMI 1640 medium (#8123340, Gibco) containing 10% FBS (#A5669701,Gibco), 1% penicillin/streptomycin, 50 M -mercaptoethanol (Beyotime, Shanghai, China), 1 mM sodium pyruvate (Beyotime) and 100 U/mL interleukin-2 (#CK24, Novoprotein, Suzhou, Jiangsu, China)

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