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GHK-based formulations, including nanoparticle conjugates, hydrogels, and clinical derivatives such as TriHex and TriHex 2.0, enhance fibroblast migration, ECM remodeling, collagen and elastin synthesis, and wound closure while providing antimicrobial activity

Possible side effects Skin rash, injection site pain

improved Fer-1s plasma stability by replacing the ethyl ester with a tert-butyl ester and adding an imine, yielding SRS16-86 (EC50 = 350 nM) with enhanced stability but reduced activity due to weaker target binding (Linkermann et al., 2014)

Because carnitine may reduce the cellular effect of thyroid hormones, physician approval is essential for patients with hypothyroidism