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Validated medical treatments are: Narrow-band UVB phototherapy (311 nm) the gold standard for extensive vitiligo Topical corticosteroids and calcineurin inhibitors (tacrolimus) applied topically The JAK inhibitors (ruxolitinib cream) recent innovation approved in 2022-2023 Melanocyte grafts for stabilized segmental forms The choice depends on the type of vitiligo, extent, age, and profile

Reading and following dosage instructions, being mindful of other medications that may also contain acetaminophen, and adhering to the rule of using the least amount for a therapeutic response are all part of responsible medication use

The present review article focuses on summarizing the physiological role of seleno-GPxs and their synthetic mimics (mainly organoselenium compounds) in the radiation response of preclinical model systems