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Table of Contents What Is Retatrutide and How Does It Work in the Body Common Side Effects and Sensations Reported With Retatrutide Managing Uncomfortable Symptoms During Treatment When to Seek Medical Advice About How You Are Feeling What Current Evidence and Clinical Trials Tell Us Scientific References Frequently Asked Questions What Is Retatrutide and How Does It Work in the Body Retatrutide is an investigational once-weekly subcutaneous injection that activates GLP-1, GIP, and glucagon receptors simultaneously, slowing gastric emptying, reducing appetite, enhancing insulin secretion, and potentially increasing energy expenditure