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Resmetirom (Rezdiffra TM ), a liver-directed thyroid hormone receptor- (THR-) agonist, received accelerated FDA approval in March 2024 as the first agent specifically indicated for non-cirrhotic MASH with moderate-to-advanced fibrosis (F2-F3), based on the MAESTRO-NASH trial demonstrating MASH resolution and fibrosis improvement

The atypical energy-related symptom (AES) profile is based on the five items of hypersomnia, increased appetite, increased weight, low energy and leaden paralysis (range 015)

Nutr Cancer 1993

Acclimation strategies to spectral quality Found in diverse ecological nichesoceans, seas, freshwater, glaciers, and landcyanobacteria are exposed to temporally, diurnally, and seasonally changing light regimes