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The duration of storage outside recommended temperature ranges should be documented, and the pharmacy should be consulted about whether the medication remains safe to use based on the specific conditions and duration of improper storage

Used needles and syringes should be placed in an FDA-cleared puncture-proof sharps container rather than household trash to prevent needle-stick injuries

Clinically, this means: if you have manageable constipation at 0.5 mg and your provider wants to escalate to 1.0 mg, expect symptoms to worsen during the transition

It allows you to address the underlying cause of tissue damage and inflammation rather than just the symptoms