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all should be discontinued when pregnancy is recognized) [1] [4] After prolonged treatment interruptions (typically 2 consecutive missed doses or longer gaps), re-titration from the initial dose may be necessary according to product-specific guidelines to minimize gastrointestinal side effects

In conclusion, combining the advantages of high PE amounts and fast onset of action provided by the IL formulation, and ensuring a prolonged interaction of peptide and PE at a relevant concentration with the stomach epithelium, are necessary to enhance oral peptide bioavailability via gastric delivery

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