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Overview of 6 years therapy of type II diabetes: a progressive disease

At first, 413 papers were identified from the databases, out of which 44 duplicates were removed, leaving 369 papers to be screened using the title and abstract

Additionally, P9 induces interleukin-6 (IL-6) secretion from the intestine, which subsequently stimulates GLP-1 secretion by intestinal L-cells and pancreatic -cells, and also affects Icam2 mRNA expression, which suggests the normal expression of Icam-2 and the effects of P9 in glucose homeostasis may require IL-6 [160] (Fig

They work by regulating appetite, improving fat metabolism, enhancing energy use, and preserving lean muscle