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Calcitonin receptor activation by amylin agonists raises a theoretical concern about bone turnover (calcitonin inhibits osteoclast activity)
It is classified as an unapproved drug
Adicionalmente, investigaciones en animales han indicado beneficios adicionales: anticonvulsivante (previene convulsiones inducidas experimentalmente), anti-estrs oxidativo (un estudio en ratas mostr que DSIP activa potentes defensas antioxidantes) y antiedema (redujo la hinchazn inflamatoria, probablemente va activacin GABA e inhibicin de histamina/serotonina)
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