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Additionally, in normal spermatozoa, oxidative stress may occur as a result of the presence of leukocytes that generate ROS in the semen, exposure to exogenous substances, spermatozoa mitochondria metabolism, and in extended semen for assisted reproductive technique (ART) [12]

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It is preventable by starting slow and using appropriate concentrations

In susceptible people its thought their skin initiates an exaggerated immune response to the toxins of Staphylococcus Aureus bacteria