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The study concluded that 1% lidocaine yielded longer-lasting local anesthesia and the depth of anesthesia was significantly higher 30 minutes after administration compared to diphenhydramine.

for the broader blend decision framework, see When Do You Actually Need a Peptide Blend

[6] In summary, aside from hypersensitivity, the use of pyridoxine should be guided by clinical necessity, and caution exercised in populations vulnerable to potential risks of excipients or overdose

This works by temporarily blocking nerve signals to the muscles which will prevent the facial muscles from contracting when making expressions