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Commercial patch safety concerns Without clinical trials or regulatory oversight, the safety profile of commercial patches is largely unknown: Ingredient quality : No verification of purity or potency Skin reactions : Adhesives and ingredients may cause irritation or allergic responses Interactions : Herbal components like berberine may interact with medications Undisclosed ingredients : Some patches may contain undeclared substances The MHRA doesnt evaluate these products before they reach the market, and adverse events arent systematically collected or reviewed
In summary, the DPP-4 inhibitors have demonstrated cardiovascular safety in multiple studies
A.RainerQ.WangJ
10.1124/jpet.102.053124 J
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