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Across GLP-1 withdrawal trials, about 60% of lost weight returned by 52 weeks, and a tirzepatide withdrawal trial also measured substantial regain
Gillespie, C
Even among those that don't report significant clinical side effects, the financial burden of these drugs, as well as the injectable nature of the most popular versions (which much be administered via subcutaneous injection), are major deterrents for many patients
B., Lee, Y., Subramaniapillai, M., Brietzke, E
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